NOS3 and endothelial dysfunction: Among them, CRP, as a significant marker of the inflammatory response, can reduce the expression of endothelial nitric oxide synthase (eNOS) and mRNA stability, promote the expression of endothelial lox-1, stimulate ROS production, and increase endothelial cell apoptosis, and thus promote endothelial dysfunction, which is the main factor of AKI [30].