Furthermore, Maeda et al. [51] induced oncogenic KrasG12D in the respiratory epithelium of TTF-1 heterozygous (TTF-1 +/-) mice and found that decreased expression of TTF-1 promotes the initiation and progression of aggressive KrasG12D-induced mucinous lung adenocarcinoma. Here, TTF1 is linked to lung colloid adenocarcinoma.