The tear level of IL-1β was elevated in both ELISA (SMD 3.78, 95% CI 2.99 to 4.57, and P < 0.001) and non-ELISA (SMD 1.02, 95% CI 0.54 to 1.50, and P < 0.001) for KC patients (Figure 2(e)). The gene discussed is IL1B; the disease is keratoconus.