The therapeutic effects of two of these drugs on glioma have been previously reported, including camptothecin, a nanoprodrug with inhibitory effects on U87-MG glioma cell proliferation [34], and sanguinarine, which can reportedly induce ROS-dependent ERK1/2 activation and autophagy cell death in glioma cells [35]. Here, MAPK3 is linked to central nervous system cancer.