At the same time, multivariate Cox analysis revealed that increased expression of CKAP2L could be an independent risk factor for poor prognosis in glioma patients in the CGGA RNA-seq (HR = 1.282; 95%CI = 1.148-1.431, P < 0.001), CGGA microarray (HR = 1.431; 95%CI = 1.225-1.671, P < 0.001), and TCGA RNA-seq (HR = 1.103; 95%CI = 1.0.26-1.187, P < 0.001) datasets. The gene discussed is CKAP2L; the disease is glioma.