TGFB1 and cancer: Moreover, KEGG pathway analysis suggested that these genes were associated with various cancer-related pathways, including ERBB pathway, MAPK pathway, mTOR pathway, renal cell carcinoma, pathway in cancer, TGF-β pathway, and Wnt pathway, which gives a clue of the underlying mechanism in the pathogenesis of ccRCC (Figure 10(b) and S4, Table 5).