Various signaling pathways, promoting tumor migration and invasion, have been reported to participate in VM formation, including those involved in vasculogenesis such as vascular endothelial (VE)-cadherin, vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR) and platelet-derived growth factor (PDGF)/PDGF receptor (PDGFR) axis, and HIF1α (3). Here, VEGFA is linked to neoplasm.