PLCB4 and obstructive sleep apnea syndrome: In the study of Yao et al., gene signal transduction networks (Signal-net) were performed to identify the key genes involved in VM formation in OSA and the top-ranked ones resulted to be Itga2, integrin subunit alpha 1 (Itga1) and integrin subunit alpha 6 (Itga6) together with protein kinase cAMP-activated catalytic subunit beta (Prkacb), actinin alpha 1(Actn1), actinin alpha 4 (Actn4), phospholipase C beta 4 (Plcb4), gap junction protein alpha 1(Gja1), and the already mentioned gene encoding for PDGFRβ and PDGFα.