In MG63 OSA cells, the inhibition of Cdh5 gene encoding for VE-cadherin with small interfering RNA (siRNA) reduced the ability of cells to form endothelial-like networks when cultured on type I collagen or Matrigel (64), and the same phenomenon has been observed in silencing the Vegf gene (65). This evidence concerns the gene CDH5 and obstructive sleep apnea syndrome.