The results revealed that the Vps34 inhibitor largely diminished the protective effect of Samm50 deficiency on Ang II-induced hypertrophy (Figures 3G,H), indicating the beneficial function of mitophagy in cardiac hypertrophy and that Samm50 regulates cardiomyocyte hypertrophy by inhibiting mitophagy. Here, SAMM50 is linked to cardiac hypertrophy.