CYP11B2 and neoplasm: Several studies (Nanba et al., 2013; Nakamura et al., 2014; Ono et al., 2014) have shown that steroidogenic enzyme H-score level alone does not necessarily represent the overall steroid hormone production capacity of an adrenocortical tumor because it only represents the hormone production ability of the tumor per unit area and per cell, and there may be several other factors such as tumor area and upstream steroidogenic enzymes of CYP11B2/1 that may also play a role in hormone production.