Therefore, both the higher CYP11B2 H-score and tumor area effect synergistically give rise to higher serum aldosterone concentration in the abnormal staining group, whereas the higher serum cortisol in the abnormal staining group could mainly result from the tumor area effect rather than the similar CYP11B1 H-score compared with the wild-type group. Here, CYP11B2 is linked to neoplasm.