TARDBP and amyotrophic lateral sclerosis: Such behavior has been described for TDP-43, a protein involved amyotrophic lateral sclerosis, whose disordered C-terminus domain contains an α-helix involved in protein-protein homodimerization and liquid-liquid phase separation (Conicella et al., 2016; Lim et al., 2016; Conicella et al., 2020).