(Yuen et al., 2020) In liver and idiopathic pulmonary fibrosis, lipid nanoparticle encapsulated heat shock protein 47 (HSP47) siRNA (ND-L02-s0201/BMS-986263) showed a significant reduction in lung weight as well as fibrosis scores and considerable enhancement in lung function (Zabludoff et al., 2017). The gene discussed is SERPINH1; the disease is idiopathic pulmonary fibrosis.