Patisiran, a lipid nanoparticle formulation of siRNA has been designed to specifically inhibit transthyretin synthesis in the liver, (Adams et al., 2018; Hoy, 2018) while givosiran, a synthetic siRNA targeted towards 5-aminolevulinic acid synthase (ALAS1) is approved for the treatment of AHP. This evidence concerns the gene TTR and anhaptoglobinemia.