DDIT4 and age-related macular degeneration: (Ray et al., 2017; Raal et al., 2020) Many studies conducted using siRNA for choroidal neovascularization caused due to age-related macular degeneration (CNV-AMD) to target vascular endothelial growth factor receptor-1 (VEGFR1) or RTP801, have shown promising results in various phases of clinical trials.