Concomitant with the increased level of ACE2 witnessed at both mRNA and protein levels in IBD patients, studies also demonstrated a higher level of ACE2 in patients with Crohn’s disease (CD) than those with ulcerative colitis (UC) (Ning et al., 2019), suggesting that ACE2 could serve as a protector against intestinal inflammation. Here, ACE2 is linked to Crohn disease.