Shi et al. (2020), Zheng et al. (2021) found that the expression of m1A regulators has great prognostic value in hepatocarcinoma and pancreatic cancer (Shi et al., 2020; Zheng et al., 2021). Gao et al. (2021) indicated that m1A regulator–mediated modification patterns play a crucial role in tumor microenvironment–infiltrating immune cells and the prognosis of colon cancer (Gao et al., 2021). Furthermore, one study demonstrated that the activation of TRM6/61 could promote tumor malignant progression via sustain tRNA in methylation status in glioma (Macari et al., 2016). The gene discussed is TRMT6; the disease is malignant colon neoplasm.