CD8A and ovarian carcinoma: Moreover, a study of 199 ovarian cancer patients showed that the presence of CD20 + B cells could improve patient survival (Milne et al., 2009), as B cells can promote the production of cytokines to induce the local lymphoid structure of the tumor, thereby stimulating the persistence of CD8+ TILs that will promote tumor cell lysis (Nielsen and Nelson, 2012).