MPO and Crohn ileitis: For instance, in a recent study, a 6-week intake of Splenda, supplemented at the maximum dose recommended by the FDA (3.5 mg/ml), had significant outcomes on ileitis (increased myeloperoxidase, MPO, activity, penetration of gut bacteria in gut wall) in mice prone to IBD (SAMP1/YitFc; SAMP), but not in healthy control AKR/J mice despite changes being observed in the gut microbiome (1).