NOS2 and colitis: In DSS-colitis male Balb/c mice, high and low doses of stevioside (100 and 50 mg/kg body weight) decreased the expression of pro-inflammatory enzymes COX-2 and iNOS, decreased the levels of MPO activity (maker of neutrophil infiltration), and restored the activities/levels of antioxidant enzymes (SOD, CAT, GST, and GSH) in colon tissue when compared with non-supplemented DSS-colitis mice (12).