In another longitudinal study with 946 stable CHD patients in the San Francisco Bay Area, Welles et al. found that 25(OH)D levels under 50 nmol/L remain independently associated with cardiovascular events, but the independent association is no longer present (adjusted HR, 1.11 [95% CI: 0.85, 1.44]) after further adjustment for potential biological mediators [i.e., blood pressure, lipids, HbA1c, CRP, and PTH; (26)]. The gene discussed is CRP; the disease is coronary artery disorder.