In one such study, using several Omics like transcriptomics, proteomics, and phospho-proteomics to examine a patient-derived xenograft mouse model, TMT labeling analysis revealed that an increase in stress hormone levels during breast cancer progression was found to cause an increase in the activity of the glucocorticoid receptor (GR) at metastatic regions ultimately reducing the survival rate. Here, NR3C1 is linked to breast carcinoma.