In a similar study, Hao et al. (97) compared the effects of febuxostat and allopurinol in reducing serum levels of IL-1, IL-4, IL-6, IL-8, TNF-α, and cyclooxygenase-2 (COX-2) in 80 patients with gout, after 1 week and 3 months of treatment. The gene discussed is PTGS2; the disease is gout.