Antiproliferative; activation of PPAR-γ, TRPV1, CB1R, DNA; protection from oxidative stress, elevated levels of endocannabinoids;  the chemopreventive effect in AOM model –reduced number of tumors, ACF, polyps; activated caspase-3, suppressed phospho-Akt protein. The gene discussed is CNR1; the disease is infectious otitis media.