Pei et al. (2019) reported that SNHG14 could serve as an oncogene by regulating the miR-944/KRAS axis via the PI3K/AKT signaling pathway. SNHG14 was also found to regulate colorectal cancer progression via the miR-32-5p/SKIL and miR-186/ATG14 axes (Ye et al., 2019; Han et al., 2020). In contrast to the aforementioned study, a single study reported that SNHG14 was significantly down-regulated in colorectal cancer cell lines compared with that in a normal cell line and SNHG14 exerts an anti-tumor effect through sponging miR-92b-3p (Zhang W. et al., 2020). Here, AKT1 is linked to colorectal cancer.