THBS4 and cancer: Furthermore, high levels of THBS4 protein have been found in several pathological processes such as cancers (Singh et al., 2002; Ma et al., 2004; Lu et al., 2008; D’Errico et al., 2009; Cho et al., 2011; Curtis et al., 2012), cardiovascular damage and remodeling (Tan et al., 2002; Mustonen et al., 2008; Cingolani et al., 2011; Frolova et al., 2012; Lynch et al., 2012) as well as liver regeneration (Klaas et al., 2016).