Additionally, the activation of integrin signaling via binding of THBS4 to ITGA2 may contribute to activation of Wnt/β-catenin pathway as ITGA2 has been shown to be instrumental for platelet-induced activation of Wnt/β-catenin signaling in MCF7 breast carcinoma cells (Zuo et al., 2019). Here, THBS4 is linked to breast carcinoma.