In diffuse large B-cell lymphoma (DLBCL), SNHG14 can stimulate crosstalk between CD8+ T cells and DLBCL cells and induce CD8+ T cells by directly targeting the immune checkpoints PD-1/PD-L1 (Zhao et al., 2019). The gene discussed is SNHG14; the disease is diffuse large B-cell lymphoma.