LINC02454 and metastatic malignant neoplasm in the lymph nodes: For instance, LINC02454 was previously reported to be upregulated in papillary thyroid cancer, was closely related to various clinicopathological features, including large tumor size, advanced clinical stage and lymph node metastasis and served as a diagnostic and prognostic biomarker for papillary thyroid cancer (Cai et al., 2018; Li Z. et al., 2021; Tan et al., 2020).