METTL3 and hepatocellular carcinoma: Huang et al. (2020a) developed a prognostic model consisting of five m6A-associated genes (KIAA1429, METTL3, YTHDF1, YTHDF2, and ZC3H13) for hepatocellular carcinoma and confirmed the good performance of this model. In addition, Wang Z. et al. (2020) also constructed a five-gene signature (METT14, WTAP, HNRNPC, YTHDF1, and IGF2BP2) derived from m6A regulators to improve the prediction of the prognosis of patients with neuroblastoma (Wang Z. et al, 2020).