Huang et al. (2020a) developed a prognostic model consisting of five m6A-associated genes (KIAA1429, METTL3, YTHDF1, YTHDF2, and ZC3H13) for hepatocellular carcinoma and confirmed the good performance of this model. In addition, Wang Z. et al. (2020) also constructed a five-gene signature (METT14, WTAP, HNRNPC, YTHDF1, and IGF2BP2) derived from m6A regulators to improve the prediction of the prognosis of patients with neuroblastoma (Wang Z. et al, 2020). This evidence concerns the gene HNRNPC and hepatocellular carcinoma.