CCAR2 and colitis: First, Gao et al. (2015) have reported that mice with systemic DBC1 deletion are resistant to colitis although the underlying mechanism is proposed to be mediated by inhibition of Foxp3, a key anti-inflammatory transcription factor, by DBC1 in regulatory T cells; it remains undetermined whether the mice with epithelial-specific deletion of DBC1 would phenocopy the systemic DBC1 KO mice in the pathogenesis of intestinal fibrosis.