LEF1 and colorectal cancer: Third, a recent investigation by Kim et al. (2018) has revealed a role for DBC1 in the regulation of colorectal cancer metastasis; DBC1 directly interacts with β-catenin and stabilizes the β-catenin/LEF1 complex to activate the transcription of metastasis-associated in colon cancer 1 (MACC1), an EMT-related molecule.