TNFSF10 and cancer: In the treatment of cancer cells with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in combination with either sublethal scale ultraviolet-B exposure or cisplatin, both the regimens elicit cytotoxic response to the cancer cells in 2D culture; however, 3D spheroid cells are significantly killed only by TRAIL/cisplatin combination and no significant cytotoxicity was inflicted by the TRAIL/ultraviolet-B module (Vörsmann et al., 2013).