TGFB1 and neoplasm: Studies of more than 10,000 tumor samples from 33 cancer types on the TCGA database have identified six immune subtypes: C1 (wound healing), C2 (INF-r dominant), C3 (inflammation), C4 (lymphocyte depletion), C5 (immunologically silent), and C6 (TGF-BETA predominates) (Thorsson et al., 2018).