Previous studies have shown that non-coding RNA (circRNA or microRNA) could regulate the proliferation, migration, and metastasis of CRC cells by targeting FOXO4 (Ryu et al., 2017; Hornsveld et al., 2018), which indicated that FOXO4 plays a vital role in the pathological process of CRC. The gene discussed is FOXO4; the disease is colorectal carcinoma.