Zhang et al. (2016) also showed that patients with acute myocardial infarction had lower levels of serum vaspin. Furthermore, administration of vaspin protected against multiple mouse cardiac injuries, including cardiomyocyte apoptosis, myocardial ischemia/reperfusion injury, and diabetic cardiomyopathy (Ke et al., 2018; Yuan et al., 2018; Li et al., 2019). Here, SERPINA12 is linked to myocardial ischemia.