Zhou et al. (2019) reported that plasma vaspin concentration was decreased in patients with acute myocardial infarction. Circulating level of vaspin was negatively correlated with C-reactive protein or NT-proBNP, two key parameters of cardiac injuries. Administration of vaspin protected against cardiac pathological remodeling in response to multiple injuries. In diabetic rats, vaspin prevented myocardial damages (Li et al., 2019). Vaspin also alleviated myocardial ischemia/reperfusion injuries (Yuan et al., 2018). Here, NPPB is linked to myocardial ischemia.