CDH1 and neoplasm: They have found the following (1): for xenograft model, OSW-1 can inhibit tumor growth with reduction of tumor size and weight (2); for orthotopic model, fewer metastatic nodules in the lungs and longer survival were observed in treated group, with downregulation of Vimentin and upregulation of E-cadherin, which means OSW-1 can inhibit metastasis mediated by EMT; and (3) for knockdown NFATc2 model, identified NFATc2 may be a pivotal factor for OSW-1-mediated effects on cell death, tumor growth, invasion, and migration.