TIMP2 and neoplasm: When the lncRNA antisense noncoding RNA in the INK4 locus (ANRIL) was silenced by siRNA in a highly metastatic SOC cell line (SK-OV-3.ip1), four downregulated genes (MMP3, metastasis associated 1 (MTA1), fibronectin 1 (FN1) and MET) and two upregulated genes, including CDH1 and TIMP metallopeptidase inhibitor 2 (TIMP2) genes were detected through tumor metastasis-related mRNA microarray analysis (80).