PPARG and breast cancer: In MCF-7 breast cancer cell line, TGZ reverses the effects induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), by inhibiting nuclear factor κB (NF-κB) and activator protein-1 DNA binding, and inhibiting matrix metalloproteinases (MMPs) which play a significant role in tissue remodeling, through a PPAR-γ-dependent mechanism (67).