Encouragingly, ROSI exerts reversing effects in chemo-resistant ovarian cancer and melanoma cells via suppression of Frizzled-1 (FZD1), which enhances the inhibition of Wnt/β-catenin pathway, and the subsequent decreased expression of MDR1/P-gp, which is a common cause of MDR (102). The gene discussed is FZD1; the disease is melanoma.