GPX3 and Familial prostate cancer: Additionally, in prostate cancer PC-3 cell line, cancer growth is attenuated via the up-regulation of E-cadherin and glutathione peroxidase 3 (GPx3) upon TGZ administration, in a dose- and PPAR-γ-dependent manner, with the downregulation of which being characteristic of epithelial-mesenchymal transition (EMT) (68).