In addition to anti-proliferative and anti-metastatic effect of PGZ on the aforementioned mice xenograft of human pancreatic cancer and colon cancer, there is also evidence of its anti-angiogenetic efficacy targeting non-small cell lung cancer (NSCLC) via PPAR-γ activation and the subsequent inhibition of NF-kB transcriptional activity (88). The gene discussed is PPARG; the disease is familial pancreatic carcinoma.