Women are more affected than men (17)Often genetically predisposed (18)Histologically, a large portion is constituted by spitzoid melanoma (23)High levels of MSHHigher rate of BRAF mutations (>90%) (27, 28)Higher median thickness of the lesionLymph node involvement is more commonDistant recurrence occurs more rarely (16, 24)When treated with immunotherapy, lower rate of colitis and higher rate of hepatitis as irAEWhen treated with immunotherapy, higher rate of CRs and higher OS (36). The gene discussed is BRAF; the disease is spitzoid melanoma.