In our study, Western blot analysis showed that VB1 induced the elevated expression of cleaved caspase 3 in SKOV3 cell line and HO8910 cell line after VB1 treatment, which suggested that VB1 induce apoptosis of ovarian cancer with a caspase signaling pathway by participating endogenous mitochondrial and exogenous death receptor signaling pathway. Here, CASP3 is linked to ovarian cancer.