Contrary to this, genetic alterations in fibroblasts growth factor receptor 3 (FGFR3), a potent receptor-tyrosine kinases (RTK) involved in growth and proliferation of cancer cells, were significantly higher in HPV-positive vs. HPV-negative tumours (13.95% vs 1.73%, p=0.017). The gene discussed is FGFR3; the disease is neoplasm.