IL33 and hematologic disorder: In hematological malignancies, alarmins such as IL-33 and Hsp-70 are commonly released, and cytokines such as IL-1 have been found to activate MCs and cause the release of IL-6 and TNF-α, while chymase from MCs has been shown to degrade IL-33 and Hsp-70 due to their ability to cause inflammation (70, 72, 73).