In tumor microenvironment, MCs release molecules like Vascular endothelial growth factor (VEGF), heparin, tryptase, Fibroblast growth factor (FGF-2) which can initiate tumor angiogenesis and molecules like Matrix metalloproteinases (MMP-9 and MMP-2) which can enable tumor niche remodeling, migration and invasiveness collectively leading to cancer progression (9). This evidence concerns the gene VEGFA and cancer.