In addition to c-KIT inhibitors, interestingly Fluvastatin, a statin drug used in the treatment of hypercholesterolemia not only suppresses IgE signaling in MCs but also induces apoptosis by inhibiting stem cell factor (SCF) induced survival signals in primary and in c-KIT mutated MCs (54). The gene discussed is KIT; the disease is familial hypercholesterolemia.