Taking into account the somatic mutations, the cytogenetic alterations and the mutations in non-coding regions, they conclude CLL relates to alterations in eight signaling pathways: B cell receptor, cell cycle regulation, apoptosis, response to DNA damage, chromatin remodeling, RNA metabolism and Notch and NF-kB pathways (7). This evidence concerns the gene NFKB1 and B-cell chronic lymphocytic leukemia.