It is found that NCT treatment did not alter the distribution of CD4+ T cells (Figure 2F), CD8+ TRM cells (CD8+ CD103+) (Figure 2G), CD4+ TRM cells (CD4+ CD103+) (Figure 2H) and CD4+ GzmB+ T cells were significantly increased in the overall tumor area after neoadjuvant chemotherapy (Figure 2I). This evidence concerns the gene CD4 and neoplasm.