Besides, through the “HCC meta co-expression network” function of the HCCDB database, we acquired genes with similar expression patterns to CDT1 in HCC and conducted further enrichment analysis of these co-expression genes (MCM2, MCM10, CDCA5, CDC45, TEDC2, GINS2, etc.)(Supplementary Figure 1A). This evidence concerns the gene CDT1 and hepatocellular carcinoma.