To explore the signaling pathways through which BTZ modulated MM cell apoptosis, we examined the CHOP transcription factor related to endoplasmic reticulum (ER) stress-induced apoptosis, CHOP-dependent death receptor 5 (DR5), and Noxa, a proapoptotic BH3-only protein. Here, TNFRSF10B is linked to Miyoshi myopathy.