This is due to generation of chromosomal fragments that stimulate the cytosolic sensing cGAS/STING pathway that promotes anti-tumor immunity through activation of T and NK cells, neoantigen recognition, and increased PD-L1 expression, and this immune system stimulation is enhanced in the background of BRCAness/HRDness (24, 27, 90, 116–118). The gene discussed is CGAS; the disease is neoplasm.