As such, TNBC typically exhibits properties favorable to immunotherapy response, including increased TILs (19), which correlates with improved outcomes in early-stage TNBC (20), higher PD-L1 expression as compared to hormone receptor positive BC (12, 13), and increased TMB giving rise to tumor neoantigen-specific T cells (2, 18, 21, 22). The gene discussed is CD274; the disease is breast cancer.