For example, in some subtypes of B-cell lymphoma, glycosyltransferase 1 domain-containing 1 (GLT1D1) is significantly upregulated and enhances PD-L1 stability through N-glycosylation; downregulation of GLT1D1 caused a decrease in glycosylated PD-L1 protein, leading to an increase in cytotoxic T-cell infiltration in the tumor microenvironment (77). This evidence concerns the gene CD274 and neoplasm.