SLC5A1 and cancer: Bidirectional metabolic feedback occurs between macrophages and breast cancer cells in which M2 like macrophages induce sodium/glucose cotransporter 1 (SGLT1) in breast cancer cells and SGLT1 enhances lactic acid secretion to promote M2 macrophage polarization (107) CCL5 activates the CCR5 receptor, which participates in metastasis of breast (9, 108) and other cancers  (109–111).