Eight genes were obtained from the analysis: COL1A2, COL4A1, ITGB4, MAPK10, PRKCB, PRKCG, RELN, and TNC. COL1A2, MAPK10, and PRKCB genes were identified as low-risk genes, while COL4A1, ITGB4, PRCKG, RELN, and TNC were defined as high-risk for the OS in patients with glioma. Here, MAPK10 is linked to central nervous system cancer.