As shown in Supplementary Figure S1, FAM46A, ATP6V1B1, DUOX2, GPER1, S1PR5, and HOXC6 were significantly differentially expressed between TAN tissues and corresponding prostate cancer tissues (Wilcoxon signed-rank test, p < 0.05), while JADE1, LRRC75A, UPK3A, and DOK6 did not show statistically differential expression between these two types of tissues (Wilcoxon signed-rank test, p > 0.05). Here, DUOX2 is linked to Familial prostate cancer.