In the immune escape mechanism of breast cancer, the intrinsic resistance factors of tumor cells including MAPK signal, PTEN mutation, WNT-β-catenin signal activation, IFN-γ signal activation, and adaptive resistance factors, such as expression immunity Checkpoint molecules, tumor stromal proliferation, and immune cell infiltration are all involved in this process (7–11). The gene discussed is IFNG; the disease is breast carcinoma.