In omega-3 plus vitamin E supplementation group significant improvement in total UPDRS compared to placebo group (in UPDRS-part I, in other parts of UPDRS no).Omega-3 fatty acids and vitamin E co-supplementation for 12 weeks in PD patients significantly improved gene expression of TNF-α, PPAR-γ and LDLR and did not have effect on levels of IL-1 and IL-8. The gene discussed is CXCL8; the disease is Parkinson disease.