SLC22A12 and hyperuricemia: Chuang W and his co-workers found that quercetin can not only attenuate hyperuricemia through regulation of renal urate transport-related proteins like renal-specific transporter (RST), organic anion transporters 1 (OAT1), glucose transporter 9 (GLUT9), but also be capable of accommodating lipid metabolism-related genes such as peroxisome proliferators activated receptor-α (PPAR-α), carnitine palmitoyltransferase-1 (CPT-1), acetyl-CoA carboxylase-2 (ACC-2) and organic cation transportor 2 (OCTN2), to protect from dyslipidemia [79].