Researchers found that besides reducing inflammatory reactions, notoginseng Fc also protect from renal fibrosis and podocyte apoptosis by inhibiting ILK and transient receptor potential cation channel 6 (TRPC6) and relieve microcirculation disturbance by modulating a disintegrin-like and metalloprotease with thrombospondin type 1 repeats member 13 (ADAMTS13) and von Willebrand factor (vWF) expression [78]. The gene discussed is VWF; the disease is renal fibrosis.