Relative to expanded iNKR‐ NK cells, expanded LIR‐1SP NK cells displayed higher degranulation upon stimulation with tumor cell lines, as well as higher expression levels of DNAM‐1 and granzyme B. Expanded NK cells with an educating KIR co‐expressing LIR‐1 had higher degranulation levels than NK cells only expressing one of the receptors. Here, GZMB is linked to neoplasm.