Karatolios and colleagues assessed pericardial and serum level of VEGF, bFGF, IL-1β and TNF-α by ELIZA in patients with viral and auto reactive pericardial effusion and concluded that the level of VEGF and bFGF are elevated in patients with inflammatory origin of PE.15 Theoretically, by considering the inflammatory process of SARS-COV-2, we expect the incidence of myopericarditis to be raised in COVID-19. This evidence concerns the gene VEGFA and pericardial effusion.