Evidence suppose the hypothesis that the clinical presentation of COVID-19 is as a result of variable immune responses to the virus.11 Blanco-Melo et al showed that SARS-COV-2 induces a particular signature and leads to significant induction of multiple proinflammatory chemokines, IL-1B,IL6,TNFand IL1RA and the serum levels of theses cytokines which are elevated.12 This evidence concerns the gene IL1B and COVID-19.