APOB and Hypertension: Schwetz et al performed a RCT in middle-aged patients with hypertension and low 25(OH) D levels and the results indicated that high-dose vitamin D supplementation had no effect on Apo A1 levels, however there was an unexpected increase in Apo B levels.44 Also, Wood A. D. et al conducted daily supplementation of vitamin D3 (400 or 1000IU) over one year showed no significant effect on APO A1, either.41 However the levels of Apo B were significantly improved in both dosage.