TIMP2 and renal fibrosis: After analyzing the expression levels of the fibrosis-related proteins including COL-I, a-SMA, and TIMP2 in the kidney tissues, we found that these proteins’ expression levels were up-regulated in the UUO group while up-regulation was relieved in the verbascoside treatment group which indicated that renal fibrosis resulting from UUO could be attenuated by verbascoside treatment.